Craig became well known internationally after he was cast as the sixth actor to portray fictional secret agent James Bond in the film series. He made his début as the character in the 2006 film, Casino Royale. He was critically acclaimed, and was nominated for a BAFTA award, for his portrayal in the film.

Craig was born in Chester, Cheshire, England. His mother, Carol Olivia (née Williams), was an art teacher, and his father, Timothy John Wroughton Craig, was the landlord of the pubs "Ring o' Bells" (in Frodsham) and "The Boot Inn", and also served as a midshipman in the Merchant Navy. Both of Craig's parents were of half Welsh descent. He was brought up in Liverpool and on the Wirral, Merseyside, and began acting in school plays at age six. Craig went to a primary school in Frodsham and Hoylake called Holy Trinity Primary School[citation needed]. He moved to London when he was sixteen to join the National Youth Theatre after a brief stay at Calday. He and his older sister, Lea, attended Hilbre High School and Calday Grange Grammar School in West Kirby. He played for Hoylake Rugby Club. He attended the Guildhall School of Music and Drama at the Barbican and graduated in 1991 after three years of study under Colin McCormack.

Craig appeared as Joe in the Royal National Theatre's production of Tony Kushner's Angels in America in November 1993. An early starring role was as 'Geordie' in the BBC's 1996 drama Our Friends in the North, with early film roles being as Angelina Jolie's rival and love interest in Lara Croft: Tomb Raider (2001), before appearing in Sam Mendes's movie Road to Perdition (2002), with Tom Hanks and Paul Newman. Other leading film roles include Sword of Honour (2001), The Mother (2003) with Anne Reid, Sylvia (2003) with Gwyneth Paltrow, Layer Cake (2004) with Sienna Miller, Enduring Love (2004) with Rhys Ifans, Steven Spielberg's Munich (2005) with Eric Bana, Infamous (2006), and The Golden Compass (2007). He recently starred in Defiance.

On 23 October 2005, Craig signed a five-film contract with EON Productions to portray James Bond. He stated that he "was aware of the challenges" of the James Bond franchise which he considers "a big machine" that "makes a lot of money". He aimed at bringing more "emotional depth" to the character. Being born in 1968, Craig is the first actor to portray James Bond to be born after the Bond series already started, and Ian Fleming, the novels' writer, had died.

Although the choice of Craig was controversial, numerous actors publicly voiced their support. Most notably, four of the five actors who had previously portrayed Bond — Pierce Brosnan, Timothy Dalton, Sean Connery, and Roger Moore — called his casting a good decision. Clive Owen, who had been linked to the role, also spoke in defence of Craig.

The first film, Casino Royale, premièred on 14 November 2006 and grossed a total of US$594,239,066 worldwide, which makes the film the highest grossing Bond film to date.

After the film was released, Craig's performance was highly acclaimed.

As production of Casino Royale reached its conclusion, producers Michael G. Wilson and Barbara Broccoli announced that pre-production work had already begun on the 22nd Bond film. After several months of speculation as to the release date, Wilson and Broccoli officially announced on 20 July 2006 that the follow-up film, Quantum of Solace, was to be released on 7 November 2008 and that Craig plays Bond with an option for a third film. On 25 October 2007, MGM CEO Harry Sloan revealed at the Forbes Meet II Conference that Craig had signed on for four more Bond films, through to Bond 25.

In 2006, Craig was invited to join the Academy of Motion Picture Arts and Sciences.

On 12 June 2008, Craig sliced the top of one of his fingers off while filming Quantum of Solace. The accident was the latest in a string of incidents surrounding the shoot, including a fire at one of the sets in Pinewood Studios, UK; a car crash that left the stunt driver in a serious condition; and an Aston Martin skidding off the roads in heavy rains while being transported to the set in northern Italy and plunging into Lake Garda.